The Isenheim Altarpiece is exhibited in the Unterlinden Museum, Colmar, France. It was originally located in the Monastery of St Anthony on the outskirts of the village of Isenheim, halfway between Colmar and Basel. The altarpiece has three sets of wings, which were opened on certain feast days, but these have now been separated and are displayed simultaneously in the main hall of the museum.

The massive work was painted between 1512 and 1516 by the shadowy figure we mistakenly call Matthias Grünewald. In fact, his actual name was Mathis Gothardt. Nikolaus of Hagenau executed the exquisitely crafted sculptures in the innermost panel.